Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme

Akhtar, Muhammad Furqan Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme. Biomedicine & Pharmacotherapy.

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Abstract

Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded
annually in the United States. Various clinical analyses and studies show that certain chronic diseases, including
cancer, interact between cell-reactive radicals rise and pathogenesis. Reactive oxygen and nitrogenous sources
include endogenous (physiological processes), and exogenous sources contain reactive oxygen and nitrogen
(xenobiotic interaction). The cellular oxidation/reduction shifts to oxidative stress when the regulation mechanisms
of antioxidants are surpassed, and this raises the ability to damage cellular lipids, proteins, and nucleic
acids.
Objective: This review is focused on how phytochemicals play crucial role against glioblastoma multiforme and to
combat these, bioactive molecules and their derivatives are either used alone, in combination with anticancer
drugs or as nanomedicine formulations for better cancer theranostics over the conventional approach.
Conclusion: Bioactive molecules found in seeds, vegetables, and fruits have antioxidant, anti-inflammatory, and
anticancer properties that may help cancer survivors feel better throughout chemotherapy or treatment. However, incorporating them into the nanocarrier-based drug delivery for the treatment of GBMs, which could be a
promising therapeutic strategy for this tumor entity, increasing targeting effectiveness, increasing bioavailability,
and reducing side effects with this target-specificity, drug internalization into cells is significantly improved, and
off-target organ aggregation is reduced.

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