Comparison of asymmetric dimethylarginine levels between pre- and post-menopausal women � a cross-sectional study from Rawalpindi

Ayub, Saddaf and Rahim, Amena and Afzal, Muhammad and Jahan, Saira and Hasan, Aisha and Zainub, Abeerah (2019) Comparison of asymmetric dimethylarginine levels between pre- and post-menopausal women � a cross-sectional study from Rawalpindi. JPMA, 69 (No. 12). pp. 1808-1811.

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Abstract

Objective: To compare serum levels of asymmetric dimethylarginine between premenopausal and
postmenopausal women, and to evaluate its relationship with time since onset of menopause.
Methods: The cross-sectional comparative study was conducted at Islamic International Medical College,
Rawalpindi, Pakistan, from April 2017 to March 2018, and comprised individuals recruited from the Gynaecology
and Obstetrics outpatient department of the Pakistan Railway Hospital in the city. The subjects were divided into
two groups; pre-menopausal women in Group I and postmenopausal in Group II. Group II was subdivided into three
categories according to time since onset of menopause. Serum asymmetric dimethylarginine levels were estimated
in each subject. Data was analysed using SPSS 21.
Results: Of the 80 subjects, there were 40(50%) in Group I with a mean age of 36.25±6.8 years, 40(50%) in Group II
with a mean age of49.83±4.35 years. There was a significant increase in mean asymmetric dimethylarginine levels
in Group II compared to Group I (p<0.05). There was also a significant increase in asymmetric dimethylarginine levels
with increase in duration since the onset of menopause (p<0.001).
Conclusion: Levels of asymmetric dimethylarginine increased significantly after menopause.
Keywords: Asymmetric dimethylarginine, Premenopausal, Postmenopausal.

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Rehabilitation and Allied Health Sciences(FRAHS) > Riphah College of Rehabiliation and Allied Sciences Islamabad
Depositing User: Dr Saira Jahan
Date Deposited: 05 May 2020 07:06
Last Modified: 05 May 2020 07:06
URI: http://research.riphah.edu.pk/id/eprint/446

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