Kiyani, Mubin Mustafa and Rehman, Hamza and Hussain, Mir Arif and Jahan, Saira and Afzal, Muhammad and Nawaz, Irum and Mahmood, Tariq and Bokhari, Syed Ali Imran (2019) Inhibition of Hyperuricemia and Gouty Arthritis in BALB/c Mice Using Copper Oxide Nanoparticles. Biological Trace Element Research.
Full text not available from this repository.Abstract
Nanoparticles are known for their unique properties and are being utilized in various disciplines of sciences. Their nanosize
enables them to higher exposure and higher availability when given orally. Gout is an inflammatory disease caused by deposition
of monosodium urate (MSU) crystal deposition into the joints. The objective of this study was to evaluate the effects of copper
oxide nanoparticles on hyperuricemia and gouty arthritis in mice. In this research, synthesized copper oxide nanoparticles of size
ranging from 30 to 50 nm were administered orally to mice having gouty arthritis and hyperuricemia. Various biochemical
markers were conducted to determine the effects of copper oxide nanoparticles. It was observed that the mice treated with CuO
NPs at various concentrations showed a significant (0.001) decrease in the serum uric acid levels in comparison with the negative
control. Furthermore, creatinine levels were also normal in comparison with the control mice. Measurement of synovial joints
also revealed that mice administered with CuO NPs had reduced inflammation of synovial joints in comparison with the negative
control. Fromthis research, it was concluded that copper oxide nanoparticles have potential in the treatment of hyperuricemia and
gouty arthritis by decreasing serum uric acid and inflammation in synovial joints.
Keywords Copper oxide . Nanoparticles . Gouty arthritis . Hyperuricemia . Uric acid . Synovial joints
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Rehabilitation and Allied Health Sciences(FRAHS) > Riphah College of Rehabiliation and Allied Sciences Islamabad |
| Depositing User: | Dr Saira Jahan |
| Date Deposited: | 05 May 2020 07:08 |
| Last Modified: | 05 May 2020 07:08 |
| URI: | http://research.riphah.edu.pk/id/eprint/454 |
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