Khan, Muhammad Muzamil and Madni, Asadullah and Tahir, Nayab and Parveen, Farzana and Khan, Safiullah and Jan, Nasrullah and Ali, Ahsan and Abdurrahim, Muhammad and Farooq, Umar and Khan, Muhammad Imran (2020) <p>Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles</p>. International Journal of Nanomedicine, Volume (15). pp. 2207-2217. ISSN 1178-2013
Full text not available from this repository.Abstract
Background: Lipid-polymer hybrid nanoparticles (LPHNP) are suitable for co-delivery of
hydrophilic and lipophilic drugs. The structural advantages of polymers and biomimetic
properties of lipids enable higher encapsulation of drugs and controlled release profile. Lipidpolymer
hybrid nanoparticles have been prepared for co-delivery of curcumin and cisplatin
for enhanced cytotoxicity against ovarian cancer.
Material and Methods: Chitosan, cisplatin, curcumin, Lipoid S75 were selected as structural
components and ionic gelationmethod was used for preparation of LPHNPs. Nanoparticles were
formed via ionic interaction of positively charged chitosan and negatively charged lipid.
Results: The optimized nanoparticles were of 225 nm with cationic charge. The encapsulation
efficiency was greater than 80% with good drug loading. The drug release profile
showed controlled release behavior of both curcumin and cisplatin simultaneously and the
absence of burst release. The in vitro therapeutic efficacy and cellular association was
evaluated using A2780 ovarian cell lines. To further investigate therapeutic efficacy, we
developed 3D spheroids as tumor model to mimic the in vivo conditions. The cytotoxicity
and uptake of co-loaded LPHNPs were evaluated on 3D spheroids and results indicated
increased chemosensitization and enhanced therapeutic efficacy of co-loaded LPHNPs.
Conclusion: Lipid-polymer hybrid nanoparticles could be a suitable platform for co-delivery
of curcumin and cisplatin for enhanced cytotoxic effect on ovarian cell lines.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Imran Khan |
| Date Deposited: | 29 Nov 2020 05:30 |
| Last Modified: | 29 Nov 2020 05:30 |
| URI: | http://research.riphah.edu.pk/id/eprint/1039 |
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