Rasul, Akhtar and Imran Khan, Muhammad and Rehman, Mujeeb and Abbas, Ghulam and Aslam, Nosheen and Ahmad, Shabbir and Abbas, Khizar and Akhtar Shah, Pervaiz and Iqbal, Muhammad and Ahmed Al Subari, Ali Mohammed and Shaheer, Talal and Shah, Shahid (2020) <p>In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug</p>. International Journal of Nanomedicine, Volume (15). pp. 7937-7949. ISSN 1178-2013
Full text not available from this repository.Abstract
Background: Cyclosporine A (CsA) is an exceptional immunosuppressant used for the
treatment of immune disorders. Niosomal vesicles are promising drug carriers that are
formed by self-association of nonionic surfactants and cholesterol in an aqueous phase.
The objective of the study was to formulate combined nonionic surfactant based vesicles
and to evaluate their in vitro characterization, release studies and in vivo studies.
Materials and Methods: Five niosomal formulations (F7 to F11) were prepared using the
thin film hydration method. The molar ratio of cholesterol and non-ionic surfactant taken was
1:1. In formulation F10, the combination of surfactants Span 20 and Brij 35 was used. The
niosomes were characterized by zeta sizer and SEM for particle size analysis, in vitro drug
release and stability studies. The pharmacokinetic studies were conducted on healthy albino
rabbits.
Results: The size of niosome was found in the range of 427.1 nm to 972.3 nm. SEM image
of optimized formulations F10 exhibit the spherical nature of niosomal vesicles. DSC
thermograms of niosomal formulations exhibited a broadened endothermic peak. The stability
study exhibited that all formulations are stable and negligible change of vesicle size and
entrapment was observed with time. The percentage drug release was significantly higher as
compared to CsA plain dispersion for all niosomal formulations at pH 1.2 and 7.4. The
release kinetic behavior showed that all preparations were best described by zero order and
can release active ingredient in a sustained manner. The pharmacokinetic data showed the
test formulation (F10) possessed greater bioavailability as compared to the reference formulation
(CsA aqueous dispersion).
Conclusion: The formulation F10 demonstrated a comparatively more delayed rate of
release with enhanced dissolution as compared to a single surfactant scheme. The F10
formulation can be a remarkable nanotechnology for prolonged delivery of CsA orally
with improved dissolution profile and bioavailability.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Imran Khan |
| Date Deposited: | 29 Nov 2020 05:30 |
| Last Modified: | 29 Nov 2020 05:30 |
| URI: | http://research.riphah.edu.pk/id/eprint/1042 |
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