Khan, Daulat Haleem and Bashir, Sajid and Khan, Muhammad Imran and Figueiredo, Patrícia and Santos, Hélder A. and Peltonen, Leena (2020) Formulation optimization and in vitro characterization of rifampicin and ceftriaxone dual drug loaded niosomes with high energy probe sonication technique. Journal of Drug Delivery Science and Technology, 58: 101763. p. 101763. ISSN 17732247
Full text not available from this repository.Abstract
The aim of the present study was to prepare niosomal formulations for dual drug therapy of ceftriaxone sodium
and poorly water-soluble rifampicin by the ecological probe sonication method. Pluronic L121 and Span 60 were
used as surface active agents and the optimization of the composition was made with the aid of Design of
Experiment (DoE) concept. Concentration levels of charge inducing agent, dicetylphosphate (DCP), and Pluronic
L121 were studied as variables. Prepared niosomes with varying concentrations of DCP and Pluronic L121
resulted in small sized niosomes with sizes ranging from 165 nm to 893 nm. During the four weeks stability
testing, the particle sizes of the empty niosomes were reduced, while the particle sizes of the drug loaded
niosomes were increased very slightly. The optimized formulations resulted in stable niosomes with high drug
entrapment efficiencies: entrapment efficiency was 99% for rifampicin and 96% for ceftriaxone. All the niosomal
formulations showed faster in vitro drug release rates as compared to bulk drug formulations. In conclusion,
ceftriaxone and rifampicin loaded niosomes prepared with Pluronic L121 and Span 60 resulted in stable, small
sized niosomes with high drug entrapment efficiencies and improved drug release profiles.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Imran Khan |
| Date Deposited: | 29 Nov 2020 05:30 |
| Last Modified: | 29 Nov 2020 05:30 |
| URI: | http://research.riphah.edu.pk/id/eprint/1055 |
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