Tufail, Saima and Siddique, Muhammad Irfan and Sarfraz, Muhammad and Sohail, Muhammad Farhan and Shahid, Muhammad Nabeel and Omer, Muhammad Ovais and Katas, Haliza and Rasool, Fatima (2021) Simvastatin nanoparticles loaded polymeric film as a potential strategy for diabetic wound healing: in vitro and in vivo evaluation. Current Drug Delivery, 18. ISSN 15672018
Full text not available from this repository.Abstract
Introduction: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds.
Aim: Aim of the present study is to fabricate nanofilm embedded with simvastatin loaded chitosan nanoparticles (CS-SIM-NPs) has been reported herein to explore the efficacy of SIM in diabetic wound healing.
Methods: The NPs, prepared via ionic gelation, were 173nm ± 2.645 in size with a zeta potential -0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated into polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization. The optimized nanofilm was applied to the wound created on the back of diabetes-induced (with alloxan injection 120 mg/kg) albino rats.
Results: The results showed significant (p < 0.05) improvement in the wound healing process compared to the diabetes-induced non-treated group. The results highlighted the importance of nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the wound site.
Conclusion: Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic wound healing agent in the industry of nanomedicines.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 04 Aug 2021 08:47 |
| Last Modified: | 04 Aug 2021 08:47 |
| URI: | http://research.riphah.edu.pk/id/eprint/1603 |
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