Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats

Akhtar, Muhammad Furqan (2021) Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY.

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Abstract

The current research was aimed to evaluate the antidiabetic activity of Terminalia citrina methanolic
extract (TCME) by streptozotocin-induced diabetes in male Wistar rats. TCME exhibited better in-vitro
antioxidant and alpha-amylase inhibitory activity as compared to other tested extracts. TCME at 250,
500, and 750mg/kg showed notable (p<.05) antidiabetic potential by lowering fasting blood glucose
level, restoring lipid level, serum amylase, HbA1c, kidney, and liver function tests as coevidenced from
histological findings of the liver, pancreas, and kidney. TCME remarkably reinstated the antioxidant enzymatic activities (CAT: 0.181 ± 0.011 IU/mg protein, SOD: 21.45 ± 1.53 IU/mg protein) and reduced lipid peroxidation level (40.60 ± 2.41 mM/mg protein) in the liver and kidney tissue of diabetic rats at 750 mg/kg dose. The acute and subacute oral toxicity study of TCME exhibited no clinical toxicity signs and mortality. Its GC-MS spectrum unveiled the existence of 10-octadecenoic acid and other compounds which might have contributed to antidiabetic potential.

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