Gul, Uzma and Khan, Muhammad Imran and Madni, Asadullah and Sohail, Muhammad Farhan and Rehman, Mubashar and Rasul, Akhtar and Peltonen, Leena (2022) Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation. Drug Delivery, 29 (1). pp. 600-612. ISSN 1071-7544
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In this article, formulation studies for terbinafine hydrochloride nanoemulsions, prepared by highenergy ultrasonication technique, are described. Pseudo-ternary phase diagram was constructed in
order to find out the optimal ratios of oil and surfactant/co-solvent mixture for nanoemulsion production. Clove and olive oils were selected as oil phase. Based on the droplet size evaluation, maximum
nanoemulsion region were determined for formulation development. Further characterization included
polydispersity index (PDI), zeta potential, Fourier transform infrared (FT-IR) spectroscopy, morphology,
pH, viscosity, refractive index, ex vivo skin permeation, skin irritation, and histopathological examination. Droplet sizes of optimized formulations were in colloidal range. PDI values below 0.35 indicated
considerably homogeneous nanoemulsions. Zeta potential values were from 13.2 to 18.1 mV indicating
good stability, which was also confirmed by dispersion stability studies. Ex vivo permeation studies
revealed almost total skin permeation of terbinafine hydrochloride from the nanoemulsions (96–98%)
in 6 hours whereas commercial product reached only 57% permeation at the same time. Maximum
drug amounts were seen in epidermis and dermis layers. Skin irritation and histopathological examination demonstrated dermatologically safe formulations. In conclusion, olive oil and clove oil-based
nanoemulsion systems have potential to serve as promising carriers for topical terbinafine hydrochloride delivery.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 05 Jun 2022 06:54 |
| Last Modified: | 05 Jun 2022 06:54 |
| URI: | http://research.riphah.edu.pk/id/eprint/1879 |
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