Frasat, Taskeen and Tulain, Ume Ruqia and Erum, Alia and Saleem, Uzma and Sohail, Muhammad Farhan and Kausar, Rizwana (2022) Aloe vera and artemisia vulgaris hydrogels: exploring the toxic effects of structural transformation of the biocompatible materials. Drug Development and Industrial Pharmacy. pp. 1-11. ISSN 0363-9045
Full text not available from this repository. (Request a copy)Abstract
Objectives: This study was aimed to evaluate the toxicity profile of hydrogels of plant-derived mucilage
from Aloe vera and Artemisia vulgaris used for various drug delivery applications, yet no such toxicity study
has been reported for the toxicity evaluation of 3 D structures. New Drug carriers should be harmless for
drug delivery applications.
Methods: Acute and sub-acute (repeated dose) oral toxicity studies were conducted following OECD 407
and 425 guidelines. In vitro toxicity through hemolysis and MTT assay were checked against RBC’s and
human macrophages respectively.
Results: The hemolysis and MTT assay showed good compatibility of hydrogels with blood components.
Mutagenicity testing showed no genotoxic effects of hydrogels. In vivo toxicity evaluation was done in
female albino rats and rabbits. General behavior, adverse effects, clinical signs and symptoms, and mortality were recorded for 14 days post-treatment which showed no significant (p < 005) abnormality.
Hematological and biochemical parameters including LFTs and RFTs appeared to be normal with slight
variations in the treated groups. The normal architecture of kidney, liver, heart and intestine was evident
upon histopathological analyses.
Conclusion: Hence, the results suggested that the 3 D structure of Aloe vera and Artemisia vulgaris based
hydrogels are safe upon ingestion and can be used for drug delivery science being cheap, natural and
biocompatible.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 05 Jun 2022 06:54 |
| Last Modified: | 05 Jun 2022 06:54 |
| URI: | http://research.riphah.edu.pk/id/eprint/1880 |
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