Efficacy of 0.1% tacrolimus in long-term management of erosive lichen planus

Kiyani, Amber and Sohail, Kanwal and Saeed, Muhammad Humza bin (2019) Efficacy of 0.1% tacrolimus in long-term management of erosive lichen planus. Journal of Dermatological Treatment. pp. 1-5. ISSN 0954-6634

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Abstract

INTRODUCTION:
Erosive oral lichen planus is a painful, chronic inflammatory disorder that often becomes a management challenge. This study documented aimed to document the response of patients with erosive OLP to 0.1% topical tacrolimus over a 12-month period or until the patient became unresponsive to therapy.
MATERIALS AND METHODS:
It is a retrospective cohort study. Retrospective data of 12 patients with recalcitrant OLP that were prescribed 0.1% tacrolimus was reviewed. Patients with a biopsy proven diagnosis of OLP who were prescribed 0.1% tacrolimus after they failed to respond to conventional corticosteroid therapy were included. Information about their response to medication initially and on flare ups were included in this study.
RESULTS:
The sample consisted of 9 women and 3 men. All patients were given 0.1% tacrolimus to be applied 3 times a day. Two patients did not respond to the treatment at all, 4 patients showed partial response to tacrolimus treatment. Six patients showed complete initial response to treatment. Four patients failed to show response to the medication following first and second flare ups.
CONCLUSION:
50% of our patients showed a suboptimal response to 0.1% tacrolimus use for erosive OLP, thus suggesting that 0.1% tacrolimus may be an ineffective option for managing erosive OLP, in some cases.

Item Type:	Article
Uncontrolled Keywords:	effectiveness, oral lichen planus, side effects, corticosteroids, tacrolimus
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Health and Medical Sciences (FHMS) > Islamic International Dental College Islamabad
Depositing User:	Dr Kanwal Sohail
Date Deposited:	27 Feb 2020 06:23
Last Modified:	27 Feb 2020 06:24
URI:	http://research.riphah.edu.pk/id/eprint/225

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