SALIVARY BIOMARKER INTERLEUKIN-8 LEVELS CORRELATED WITH DIFFERENT PARAMETERS OF NASWAR (SMOKE LESS TOBACCO) USAGE

Sohail, Kanwal and Siddiqi, Khalid Mahmood and Baig, Muhammad Zeeshan and Sahibzada, Haafsa Arshad and Shahid, Abdul Manan (2019) SALIVARY BIOMARKER INTERLEUKIN-8 LEVELS CORRELATED WITH DIFFERENT PARAMETERS OF NASWAR (SMOKE LESS TOBACCO) USAGE. Pakistan Oral and Dental Journal, 39 (1). pp. 24-9. ISSN 1012 800

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Abstract

Use of smokeless tobacco is more dangerous than smoked tobacco. Objective of current cross sectional
study was to find out the levels of interleukin-8 cytokine in naswar users and its stratification
according to age of user, type, frequency, duration and site of placement of naswar. A total of 30
naswar users were recruited. Un-stimulated saliva samples were collected and analyzed by using an
enzyme-linked immunosorbent assay (ELISA) technique. Data was entered in SPSS version 22. Age,
duration of use of naswar, frequency of use, type of naswar used and site of placement of naswar in
oral cavity were analyzed and one way ANOVA test followed by post hoc tukey analysis and Pearson
correlation was also applied.
Levels of salivary IL-8 were found to be 173.48±46.52pg/ml. The mean duration of naswar usage was
7.17±6.33 years. No statistical significant difference was found in any parameter other than frequency
of naswar usage in which p value (0.037) is less than 0.05. Pearson correlation analysis revealed that
the age and duration of naswar usage, were not correlated to the levels of salivary biomarker IL-8.
A higher level of IL-8 was found in naswar users. The statistically significant association was found
between the levels of salivary biomarker IL-8 and frequency of naswar usage. On the other hand no
association or correlation were found between IL-8 and age, duration, type and site of naswar placement

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