CYTOMORPHOMETRY OF BUCCAL SMEARS OF NICOTIANA TABACUM (NASWAR) USERS: A PILOT STUDY

Masood, Rabia and Zaib, Nadia and Jaffar, Rozinah and Khan, Khola Ahmed and Javed, Munazza and Raza, Ali and Umer, Naila (2014) CYTOMORPHOMETRY OF BUCCAL SMEARS OF NICOTIANA TABACUM (NASWAR) USERS: A PILOT STUDY. Pakistan Oral and Dental Journal, 34 (3). pp. 445-448. ISSN 1012 8700

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Abstract

The objective of the current study was to asses the cytomporphometric changes in buccal mucosal
smears of naswar users. The study groups consisted of 24 subjects divided into two groups i.e A control
group and B naswar users of ages between 15yrs-60yrs. Cellular diameter CD,nuclear diameter
ND and nuclear to cytoplasmic ratio N/C ratio was assessed in buccal mucosal smears taken from
clinically normal mucosa of naswar users and normal subjects using exfoliative cytology. The mean
cellular diameter of goup A and B was 43.93μm and 44.13μm respectively.The mean nuclear diameter
of control group and naswar users was 9.99μm and 11.88μm respectively.And the mean N/C ratio of
group A and B was 1: 4.42 and 1: 3.71 respectively.The independent T test showed significant results
(p ≤ 0.000) for nuclear diameter ND and N/C ratio both. Cytomorphometric changes in cellular
diameter,nuclear diameter and N/C ratio assessed by our study depict only cause effect relationship
between naswar and and association of these changes with dysplasia or premamlignancy needs further
verification with the help of specific immunomarkers.

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