Antidiabetic Potential of Mangifera indica L. cv. Anwar Ratol Leaves: Medicinal Application of Food Wastes

Saleem, Mohammad and Tanvir, Muiz and Akhtar, Muhammad Furqan and Iqbal, Mazhar and Saleem, Ammara (2019) Antidiabetic Potential of Mangifera indica L. cv. Anwar Ratol Leaves: Medicinal Application of Food Wastes. Medicina, 55 (7). p. 353. ISSN 1010-660X

Text (Research article) medicina anwar ratol.pdf - Published Version Download (2MB)

Abstract

Background and objectives: Anwar Ratol is one of the most famous cultivar of mango in South
Asia, especially Pakistan. Mango leaves are left as food waste. This study evaluated the potential of
mango (Anwar Ratol) leaves for their use against diabetes mellitus. Material and Methods: In this study,
hydro-alcoholic extract of the plant leaves was prepared and evaluated by electrospray ionization
mass spectroscopy (ESI-MS) and high-performance liquid chromatography (HPLC) for the presence of
phytochemicals. The plant extract was administered to Alloxan induced diabetic mice followed by
evaluation through oral glucose tolerance test; determination of postprandial glucose, body weight,
lipid profile and histopathological evaluation of pancreas. Results: Chemical evaluation revealed the
presence of mangiferin, rhamnetin, catechin, epicatechin, iriflophenone 3-C-�-D-glucoside, gallic acid
and other phenolic and flavonoid compounds. The plant extract exhibited a decrease in postprandial
blood glucose following seven days therapy in diabeticmice. The extract also prevented the rise in blood
glucose level as determined by glucose tolerance test in diabetic mice. Furthermore, therapy of diabetic
mice with the extract prevented a decrease in body weight and decline in beta-cell mass associated with
alloxan and improved lipid profile. Conclusion: The findings of the study clearly suggested that the leaf
extract of the plant might possess anti-diabetic activity possibly due to the presence of mangiferin and
other phytochemicals such as phenolic and flavonoid compounds. This study will serve as a basis for
the use of mango leaf extract against diabetes. Furthermore, this study will also provide basis for the
bioassay-based fractionation and isolation of active principles responsible for the antidiabetic potential
of mango leaves.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore
Depositing User:	Dr. Muhammad Furqan Akhtar
Date Deposited:	06 Jun 2020 08:14
Last Modified:	06 Jun 2020 08:14
URI:	http://research.riphah.edu.pk/id/eprint/350

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