Ahmad, Zulcaif and Khan, Muhammad Imran and Siddique, Muhammad Irfan and Sarwar, Hafiz Shoaib and Shahnaz, Gul and Hussain, Syed Zajif and Bukhari, Nadeem Irfan and Hussain, Irshad and Sohail, Muhammad Farhan (2020) Fabrication and Characterization of Thiolated Chitosan Microneedle Patch for Transdermal Delivery of Tacrolimus. AAPS PharmSciTech, 21 (2). ISSN 1530-9932
Full text not available from this repository. (Request a copy)Abstract
Microneedle patch is a prominent strategy with minimal invasion and painless application to improve skin penetration of drug molecules. Herein, we report microneedle patch (MNP) as an alternative to the oral route for the systemic delivery of tacrolimus (TM), an immunosuppressant drug. Thiolated chitosan (TCS) based microneedle patch was fabricated and characterized in vitro and in vivo for its mechanical strength, skin penetration, drug release, and skin irritation. The MNP having 225 needles with 575 μm showed good mechanical properties in terms of tensile strength and percentage elongation. The skin penetration showed 84% penetration with no breakage. Histology of the mice skin after insertion showed the penetration of needles into the dermis. In vitro release and ex vivo permeation studies through Franz diffusion cell showed the sustained release (82.5%) of TM from the MNP with significantly higher (p < 0.05) skin permeation as compared with controls, respectively. Moreover, in vivo biocompatibility in rats showed the safety of the material and patch. Thus, the TCS microneedle patch has the potential to be developed as a transdermal delivery system for tacrolimus with improved bioavailability and sustained release over a longer period.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 19 Apr 2020 05:37 |
| Last Modified: | 19 Apr 2020 05:37 |
| URI: | http://research.riphah.edu.pk/id/eprint/381 |
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