Islam, Arshad and Ain, Quratul and Munawar, Amna and Corrêa Junior, José Dias and Khan, Ajmal and Ahmad, Farhan and Demicheli, Cynthia and Shams, Dilawar Farhan and Ullah, Ikram and Sohail, Muhammad Farhan and Yasinzai, Masoom and Frézard, Frédéric and Nadhman, Akhtar (2020) Reactive oxygen species generating photosynthesized ferromagnetic iron oxide nanorods as promising antileishmanial agent. Nanomedicine, 15 (8). pp. 755-771. ISSN 1743-5889
Full text not available from this repository.Abstract
Aim: To investigate the photodynamic therapeutic potential of ferromagnetic iron oxide nanorods (FIONs), using Trigonella foenum-graecum as a reducing agent, against Leishmania tropica. Materials & methods: FIONs were characterized using ultraviolet visible spectroscopy, x-ray diffraction and scanning electron microscopy. Results: FIONs showed excellent activity against L. tropica promastigotes and amastigotes (IC50 0.036 ± 0.003 and 0.072 ± 0.001 μg/ml, respectively) upon 15 min pre-incubation light-emitting diode light (84 lm/W) exposure, resulting in reactive oxygen species generation and induction of cell death via apoptosis. FIONs were found to be highly biocompatible with human erythrocytes (LD50 779 ± 21 μg/ml) and significantly selective (selectivity index >1000) against murine peritoneal macrophages (CC50 102.7 ± 2.9 μg/ml). Conclusion: Due to their noteworthy in vitro antileishmanial properties, FIONs should be further investigated in an in vivo model of the disease.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 19 Apr 2020 05:38 |
| Last Modified: | 19 Apr 2020 05:38 |
| URI: | http://research.riphah.edu.pk/id/eprint/383 |
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