Rauf, Ayesha and sohail, Muhammad Farhan and Sarwar, Hafiz Shoaib and Amin, Umair and Naveed, Sara and Ali, Imran and Saleem, waqas and Razzaq, Sobia and Rehman, Mubashar and Shahnaz, Gul (2020) Tuberculosis Resistance and Nanoparticles: Combating the Dual Role of Reactive Oxygen Species in Macrophages for Tuberculosis Management. Critical Reviews in Therapeutic Drug Carrier Systems. ISSN 0743-4863 (In Press)
Full text not available from this repository. (Request a copy)Abstract
Increasing drift in antimicrobial therapy failure against mycobacterium, the causative agent of tuberculosis, and the advent of extended resistant strains strongly demands to discover mechanisms underlying the development of drug resistance. The emergence of resistance against anti-tuberculosis drugs has reached an alarming level in various parts of the world, providing an active platform for designing new targeted drug delivery overcoming these mechanisms. Reactive oxygen species (ROS) impart an important role in controlling pathogenesis of tuberculosis. Upon macrophage activation, ROS are produced inside macrophage that directly kills the resident bacteria. These ROS possess a dual character as they can kill macrophage along with the resident bacteria. Targeting these ROS can play a remarkable role in overcoming the resistance of conventional drugs. Nanoparticles have evolved as a potential drug carrier for the targeted delivery and overcoming various resistance mechanisms against antimicrobials. Receptor-mediated targeting of macrophages via different nanoparticles can be a promising strategy to combat drug resistance and enhanced efficacy of old-fashioned anti-mycobacterial agents.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmaceutical Sciences (FPS) > Riphah Institute of Pharmaceutical Sciences Lahore |
| Depositing User: | Dr Muhammad Farhan Sohail |
| Date Deposited: | 19 Apr 2020 05:43 |
| Last Modified: | 19 Apr 2020 05:43 |
| URI: | http://research.riphah.edu.pk/id/eprint/384 |
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