Jahan, Saira and Rahim, Amena and Afzal, Muhammad and Naveed, Abdul khaliq and Ayub, Saddaf and Hasan, Aisha (2020) Association of single nucleotide polymorphism of transforming growth factor ?1 (T29C) in breast cancer patients: a case control study in Rawalpindi. JPMA, 70 (3). pp. 390-393.
Full text not available from this repository.Abstract
Objective: To determine the association of single nucleotide polymorphism in three CC, TT and TC
g e n o t y p e s o f t r a n s f o rm i n g g r o w t h f a c t o r 1 T 2 9 C i n b r e a s t c a n c e r p a t i e n t s .
Methods: The case-control study was conducted from April 2017 to April 2018 at the Islamic
International Medical College, Rawalpindi, Pakistan, in collaboration with Nuclear Oncology Medicine
and Radiotherapy Institute and Holy Family Hospital, Rawalpindi. Using convenience sampling, breast
cancer cases and healthy controls were enrolled. All investigations were done using standardised
laboratory protocols. The outcomes were determined in terms of association of single nucleotide
polymorphism of transforming growth factor 1with breast cancer. Data was analysed using SPSS
21.
Results: Of the 150 subjects, 80(53.3%) were cases and 70(47.7%) were healthy controls. Among the
cases, the most frequent genotype was CC 38(47.5%) followed by TC 26(32.5%) and TT 16(20%).
Among the controls, the corrsesponding values were 50(71.42%), 13(18.5%) and 7(10%). Transforming
growth factor 1 TC genotype was strongly associated with the increased risk of developing breast
cancer (odds ratio: 3.79).
Conclusion: The incidence of breast cancer was markedly lower among women with CC genotype
compared to those with CT or TT genotypes.
Keywords: Breast cancer, Genotype, Single nucleotide polymorphism, Transforming growth factor.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Rehabilitation and Allied Health Sciences(FRAHS) > Riphah College of Rehabiliation and Allied Sciences Islamabad |
| Depositing User: | Dr Saira Jahan |
| Date Deposited: | 05 May 2020 07:07 |
| Last Modified: | 05 May 2020 07:07 |
| URI: | http://research.riphah.edu.pk/id/eprint/450 |
Actions (login required)
 |
View Item |
