Surfactant-Assisted Wet Granulation: A Simpler Approach to Improve Solubility and Sustain Ketoprofen Release

Shamim, Rahat and Shafique, Sana and Kanwal, Ummarah and Hussain, Khalid and Asif, Noman and Ijaz, Sana and Abbas, Nasir and Bukhari, Nadeem (2019) Surfactant-Assisted Wet Granulation: A Simpler Approach to Improve Solubility and Sustain Ketoprofen Release. LATIN AMERICAN JOURNAL OF PHARMACY, 38. pp. 281-290.

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Abstract

Ketoprofen granules were prepared by surfactant-assisted wet granulation (SAWG) using different concentrations of Soluplus®, polyethylene glycol (PEG) 6000 and 4000 grades and characterized for physicochemical and dissolution characteristics. FTIR examined any drug-excipients interactions. Granule size, percent yield, bulk and tap density, Hausner’s ratio, and angle of repose of granules were found to be 571 ± 0.81 µm, 93.1 ± 0.84 %, 0.223 ± 0.01g/mL, 0.231 ± 0.002 g/mL, 1.098 ± 0.005, 33.81 ± 0.23°, respectively. Granules with 1% Soluplus® revealed highest solubility (3.09 mg/mL), but with 58.3% ketoprofen release until 12 h. Granules containing 5% PEG-6K demonstrated improved solubility as compared to pure drug, i.e. 2.81 mg/mL vs 0.010 mg/mL and release comparable to that of USP-stipulated sustained release pattern following Weibull model (β = 1.08) and showing erosion-controlled release. FTIR indicated no chemical interaction between ketoprofen and excipient in granule formulation. The SAWG successfully ameliorated ketoprofen solubility and sustained its release.

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